中嶋　一行（教授）

ナカジマ　カズユキ

専門分野 神経化学・神経薬理学
担当科目 生物学A・B、細胞生物学、演習Ⅰ・Ⅱ、生命科学(ゲノムと生命の話・共通科目)
研究テーマ 神経系におけるグリア細胞の機能解析

取材申し込み

研究者情報詳細

工学研究科　生命情報工学専攻

  • 専門分野 神経化学、神経細胞生物学
    担当科目 生物学 A・B、細胞生物学
    研究テーマ (1) 神経系におけるグリア細胞の役割
    (2) 神経系の傷害・修復・再生メカニズム
    略歴 学歴
    1953年　岩手県生まれ
    1976年　岩手大学農学部農芸化学科卒業
    1978年　岩手大学大学院農学研究科修士課程修了
    職歴
    1978年　国立武蔵療養所・神経センター、流動研究員
    1983年　　　　　同　研究員
    1990年　国立精神・神経センター、室長
    1999年　創価大学、生命科学研究所、講師
    2001年　　　　　同　助教授
    2007年　創価大学、工学部、教授
    主な著書論文 (1) Nakajima K, Reddington M, Kohsaka S. and Kreutzberg GW.
    Induction of urokinase-type plasminogen activator in rat facial nucleus by axotomy of the facial nerve.
    J. Neurochem. 66 (1996) 2500-2505.
    (2) Nakajima K, Kikuchi Y, Ikoma E, Honda S, Ishikawa M. Liu Y.and Kohsaka S.
    Neurotrophins regulate the function of cultured microglia.
    Glia 24 (1998) 272-289.
    (3) Nakajima K, Honda S, Tohyama Y, Imai Y, Kohsaka S, KuriharaT.
    Neurotrophin secretion from cultured microglia.
    J. Neurosci. Res. 65 (2001) 322-331.
    (4) Nakajima K, Kohsaka S.
    Neuroprotective roles of microglia in the central nervous system.
    In: Microglia in the regenerating and degenerating central nervous system (WJ Streit, ed), pp188-208,
    Springer-Verlag, New York, 2001
    (5) Nakajima K, Tohyama Y, Kohsaka S, Kurihara T.
    Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF)
    without induction of deleteriousfactors in vitro.
    J. Neurochem. 80 (2002) 697-705.
    (6) Nakajima K, Kurihara T, Kohsaka S.
    Molecular mechanisms determining opposed functional states of microglia.
    Current Neuropharmacology, 1 (2003) 245-265.
    (7) Nakajima K, Kohsaka S.
    Microglia: Neuroprotective and neurotrophic cells in the central nervous system.
    Current Drugs-Cardiovascular & Haematological Disorders, 4 (2004) 65-84.
    (8) Nakajima K, Kohsaka S.
    Response of microglia to brain injury.
    In: neuroglia second edition (H Kettenmann and BR Ransom, ed), pp 443-453,
    Oxford University Press, New York, 2005.
    (9) Nakajima K, Graeber MB, Sonoda M, Tohyama Y, Kohsaka S, Kurihara T.
    In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion.
    J Neurosci Res. 84 (2006) 348-359.
    (10) Matsushita Y, Nakajima K, Tohyama Y, Kurihara T, Kohsaka S.
    Activation of microglia by endotoxin suppresses the secretion of glial cell line-derived neurotrophic factor (GDNF)
    through the action of protein kinase Ca (PKCa) and mitogen-activated protein kinases (MAPKs).
    J Neurosci Res. 86 (2008) 1959-1971.
    (11) Yamamoto S, Nakajima K, Kohsaka S.
    Macrophage-colony stimulating factor (M-CSF) as an inducer of microglial proliferation in axotomized rat facial
    nucleus.
    J Neurochem. 115 (2010) 1057-1067.
    (12) Yoshino Y, Yamamoto S, Kohsaka S, Oshiro S, Nakajima K.
    Superoxide anion contribute to the induction of tumor necrosis factor alpha (TNFα) through activation of the MKK3/6-p38
    MAPK cascade in rat microglia.
    Brain Res. 1422 (2011) 1-12.
    (13) Nakajima K, Kohsaka S.
    Interaction of microglia with neurons and astrocytes under lesioned neuronal conditions.
    In: neuroglia third edition (H Kettenmann and BR Ransom, ed), pp 677-686,
    Oxford University Press, New York, 2012.
    (14) Yamamoto S, Kohsaka S, Nakajima K.
    Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus.
    Glia. 60 (2012) 570-581.
    (15) Ichimiya T, Honda Y, Yamamoto S, Kikuchi R, Kohsaka S, Nakajima K.
    Functional down-regulation of axotomized rat facial motoneurons.
    Brain Res. 1507 (2013) 35-44.
    (16) Takezawa Y, Kohsaka S, Nakajima K.
    Transient down-regulation and restoration of glycogen synthase levels in axotomized rat facial motoneurons.
    Brain Res. 1586 (2014) 34-45.
    (17) Takezawa Y, Baba O, Kohsaka S, Nakajima K.
    Accumulation of glycogen in axotomized adult rat facial motoneurons.
    J Neurosci Res. (2015) 93(6):913-921. doi: 10.1002/jnr.23546.
    (18) Sudo K,Takezawa Y, Kohsaka S,Nakajima K.
    Involvement of nitric oxide in the induction of interleukin-1 beta in microglia.
    Brain Res. 1625 (2015)121-134.
    所属学会 日本神経化学会（評議員）、日本神経科学会、日本生化学会、日本農芸化学会、
    Society for Neuroscience（北米神経科学会）

ページ公開日：2017年08月07日
Search-internal-code:faculty-profiles-2017-