Nobuyuki Nishibe | Faculty List | Soka University

Assistant Lecturer

Nobuyuki Nishibe

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Faculty of Science and Engineering Department of Life Science and Technology

Faculty of Science and Engineering Department of Science and Engineering for Sustainable Innovation

Specialized Field	Biochemistry
Research theme	Artificial control of biomolecular machines using photoresponsive proteins
research content	Intracellular signal transduction is controlled by the complex interactions of a wide variety of proteins. Small G proteins are guanine nucleotide-binding proteins that play an important role in intracellular signal transduction. Small G proteins function as biomolecular switches, activating them when they bind to GTP and transmitting downstream signals, and inactivating them when they bind to GDP, terminating downstream signal transduction. In this study, we attempt to artificially control the molecular switch using light by incorporating a light-responsive nanodevice into this molecular switch mechanism.
Subjects in charge	Biochemistry experiments, molecular biology experiments, microbiology experiments
Main career, work history, and academic background	2017 Graduated from the Department of Bioinformatics and Engineering, Faculty of Engineering, Soka University 2019: Completed Master's program in Bioinformatics Engineering at the Graduate School of Engineering, Soka University 2024: Graduated from the Graduate School of Engineering, Soka University, Department of Bioinformatics and Life Sciences (Doctor of Engineering)
Affiliated academic societies and organizations	Japanese Biochemical Society Biophysical Society of Japan American Biophysical Society
Main Papers and Publications	“Photocontrol of small GTPase Ras fused with a photoresponsive protein” Nobuyuki Nishibe and Shinsaku Maruta, The Journal of Biochemistry (2024) mvae017, https://doi.org/10.1093/jb/mvae017 Published online: 15 February 2024

Specialized Field	Biochemistry
Research theme	Artificial control of biomolecular machines using photoresponsive proteins
research content	Intracellular signal transduction is controlled by the complex interactions of a wide variety of proteins. Small G proteins are guanine nucleotide-binding proteins that play an important role in intracellular signal transduction. Small G proteins function as biomolecular switches, activating them when they bind to GTP and transmitting downstream signals, and inactivating them when they bind to GDP, terminating downstream signal transduction. In this study, we attempt to artificially control the molecular switch using light by incorporating a light-responsive nanodevice into this molecular switch mechanism.
Subjects in charge	Biochemistry experiments, molecular biology experiments, microbiology experiments
Main career, work history, and academic background	2017 Graduated from the Department of Bioinformatics and Engineering, Faculty of Engineering, Soka University 2019: Completed Master's program in Bioinformatics Engineering at the Graduate School of Engineering, Soka University 2024: Graduated from the Graduate School of Engineering, Soka University, Department of Bioinformatics and Life Sciences (Doctor of Engineering)
Affiliated academic societies and organizations	Japanese Biochemical Society Biophysical Society of Japan American Biophysical Society
Main Papers and Publications	“Photocontrol of small GTPase Ras fused with a photoresponsive protein” Nobuyuki Nishibe and Shinsaku Maruta, The Journal of Biochemistry (2024) mvae017, https://doi.org/10.1093/jb/mvae017 Published online: 15 February 2024

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