Soka University Glycan and Life Systems Integration Center (GaLSIC)

Unraveling the Mysteries of Glycans to Illuminate the Future of Life Sciences

The Soka University Glycan Life System Integration Center (GaLSIC) was established in 2021 with the aim of elucidating biological phenomena through the integration of glycan biology and glycan informatics. This institute researches the impact of glycans on biological phenomena using techniques from both biology and information science, contributing to the development of a new academic field.

Glycoscience Portal developed by Prof. Kinoshita GlyCosmos
International Glycan Structure Repository server GlyTouCan

News

About the Research Center

Institution’s Name Glycan and Life Systems Integration Center (GaLSIC)
(Japanese: 糖鎖生命システム融合研究所)
Establishment Date 1st April 2019

Director’s Greeting

Glycans are considered the third chain of life, following nucleic acids (DNA) and proteins, and they have a significant role in life phenomena including development, infection, immunity, nervous system, etc. Different types of translated proteins undergo glycosylation and perform a variety of functions in the human body. Glycans also provide a diversity of functions to proteins and increase the efficiency of several biological processes. Moreover, lipids in the cellular membrane also undergo multiple types of glycosylation. In this manner, glycoproteins and glycolipids are widely distributed in the body and deeply involved in diverse biological reactions. However, because of the complexity of their structures and biosynthetic processes, analysis of glycans is more complicated than genome research, and their functions in many essential biological phenomena which have not been fully discovered.
Currently, big data accumulation of various experimental data is the subject of much attention, and data science and mathematical science to make use of such data are becoming increasingly important. By introducing data science and mathematical science to glycan studies, remarkable results are expected. In April 2019, we established the Glycan and Life Systems Integration Center (GaLSIC), which integrates glycobiology (biological studies involving glycans) and glycoinformatics (informatics studies of glycans) to answer essential questions of the life sciences. Furthermore, in January 2021, to create a further leap forward in these fields of study, we have reorganized the center by adding new members specializing in data science, mathematical science, and bioscience.
At present, the importance of glycans is recognized not only in Japan but also in many other countries. Glycans are involved in all life phenomena. Therefore, their application covers not only diseases such as cancer, hereditary diseases, and lifestyle-related disease but also all areas of biology, agriculture, and medical science. We are committed to further promoting research in this new fusion area we are creating, aiming to understand the essence of life phenomena involving glycans.

Director Shoko Nishihara

Aim

Glycans, known as the third life chain after genomic DNA and proteins, are involved in various biological phenomena such as development, immunity, and neurotransmission. However, compared to research on genomic DNA and proteins, analysis of glycans is more complex, and their physiological functions have not yet been fully elucidated. Currently, big data based on the accumulation of various experimental data is gaining attention for it is the key to understand the essence of various life phenomena involving glycans. Therefore, it is necessary to have not only biological knowledge and skills but also knowledge and skills in information science such as data science, statistics, and mathematical science to utilize big data.
Hence, the Institute was established to create a new fusion field by bringing together experts in the fields of biology and information science to conduct research that integrates glycobiology and glyco-informatics, and to understand the nature of life phenomena involving glycans.

This image illustrate the overview of GaLSIC
Glycans and Signal Transduction that work in Mouse ES Cells
Nishihara, S. (2018). Glycans in stem cell regulation: from Drosophila tissue stem cells to mammalian pluripotent stem cells. FEBS letters C

Joint Research

With the aim to create a new academic field that integrates glycobiology and glycol-informatics, the institute is conducting joint research with researchers from abroad and Japan utilizing the institute`s equipment and databases.
In April 2022, the "Glycoscience Collaboration Network" consisting of GalSIC, the institute for Glyco-core Research (iGCORE) Tokai National Higher Education and Research System, and the institute of Exploratory Research Center on Life and Living Systems (ExCELLS) National Institutes of Natural Sciences was approved as a "Joint Usage/Collaborative Research Center" by the Ministry of Education, Culture, Sports, Science and Technology.

Colloquium

Research presentation and studies on respective research topics are conducted by the institute’s staffs and external research collaborator regularly.

Research Publication

The research center publishes its research report “Glycan and Life System Integration Center Bulletin” that summarizes research result annually.

Close

Facility

Server

  • Managing GlyCosmos repositories and databases.

https://glycosmos.org/

https://glytoucan.org/

Confocal microscopy LSM700(ZEISS Microscopy Company)

  • Laser microscope using confocal optics as a light source
  • Fluorescent images of cultured cells and tissue sections labeled with fluorescent substances can be acquired.
  • Time-lapse imaging of live cells is also possible.

BD FACSAriaTM III Cell Sorter(Becton Dickinson Company, Ltd.)

  • Cells labeled with fluorescent substances can be mixed with fluid and irradiated with laser light to analyze cell size and internal structure, and to quantify the amount of fluorescent substances on the cell surface.
  • Specific cells can also be aseptically aliquoted.

QuantStudio12K Flex Real-Time PCR System(Applied BiosystemsⓇ)

  • This instrument is capable of quantifying template DNA by measuring the increase in PCR amplification products over time.
  • It can quantify expression levels of specific genes in cultured cells and tissues.

Cryostat CM1950(Leica)

  • Equipment for cutting frozen tissue into thin slices at low temperatures
  • Able to prepare tissue specimens for observation under an optical microscope

Cultivation Room

  • A bio-clean bench for handling cultured cells is installed.
  • A CO2 incubator is installed for cell culture.

P2 Laboratory

  • Biosafety Level 2 Laboratory.
  • Installed with a biological safety cabinet (Class IIA).

Radio Isotope (RI)Laboratory

  • Laboratory for operating radioisotopes.

Drosophila Laboratory

  • Breeding mutants and RNAi strains of various genes.
  • Tissues can be dissected and observed under a stereomicroscope.
Close

Publication

Members

Research Center Members (Full)

Director・Distinguished Professor

Shoko Nishihara

Deputy Director・Professor

Kiyoko F. Aoki-Kinoshita

Research Professor

Kiyohiko Angata

Professor

Tatsuo Unemi

Professor

Sayaka Takase

Professor

Akira Togayachi

Associate Professor

Kazuo Fujiwara

Research Lecturer

Kazuyoshi Itoh

Research Lecturer

Achille Zappa

Research Lecturer

Yukie Taylor

Research Center Members (Concurrent)

Professor

Masayasu Atsumi

Professor

Masamichi Ikeguchi

Professor

Hideki Kawai

Professor

Shuichiro Goda

Professor

Norihiko Shinomiya

Associate Professor

Daisuke Kasamatsu

Close

Activity

Publications

List of recent publications authored by GaLSIC members.

2023.07.05 Synthesis and molecular structure of V-shaped liquid crystalline compounds: Spectroscopic, mesomorphic, DFT investigations, electrochemical and fluorescence studies.
Salwadi NFL, Ooi CC, Yeap GY, Suah FBM, Cherin S, Ito MM, Kikuchi K, Fukaya R, Kaneko K, Shimizu A. Journal of Molecular Structure. 2023; 1283: 135304. https://doi.org/10.1016/j.molstruc.2023.135304.
2023.05.01 Maximizing External Action with Information Provision Over Multiple Rounds in Online Social Networks
Miyashita M, Shinomiya N, Kasamatsu D, Ishigaki G. IEICE Transactions on Information and Systems. 2023 May ( Accepted, To be published); E106-D(5): 847-855.
2023.01.25 Simultaneous determination of heparan sulfate, chondroitin/dermatan sulfates, and hyaluronan glycosaminoglycan disaccharides by high-performance liquid chromatography using a reverse-phase column with adamantyl groups
Hanamatsu H, Makino S, Ohara M, Suda G, Yokota I, Nishihara S, Sakamoto N, Furukawa JI. J Chromatogr A. 2023 Jan 25; 1689: 463748. doi: 10.1016/j.chroma.2022.463748. PMID: 36586283.
2023.01.18 A Method for Reducing the Instability of Negawatts Considering Changes in the Behavior of Consumers
Takai K, Tamura Y, Shinomiya N. Energies 16. 2023; 3: 1072. doi: 10.3390/en16031072. (IF:3.252,CiteScore:5.0)
2023.01.13 Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry.
Murakami K, Tamura R, Ikehara S, Ota H, Ichimiya T, Matsumoto N, Matsubara H, Nishihara S, Ikehara Y, Yamamoto K. Biochem J. 2023 Jan 13;480(1):41-56. doi: 10.1042/BCJ20220339. PMID: 36511224; PMCID: PMC9987951.
2023.01.05 Introducing Inductive Bias on Vision Transformers through Gram Matrix Similarity based Regularization.
Mormille LH, Broni-Bediako C, Atsumi M. Artifi cial Life and Robotics. 2023; 28(1):106-116.
2022.12.27 Length-Based Curriculum Learning for Efficient Pre-training of Language Models.
Nagatsuka, K., Broni-Bediako, C. & Atsumi, M. New Generation Computing. 2023 (to appear); 41(1).
2022.12.02 Worldwide Glycoscience Informatics Infrastructure: The GlySpace Alliance
Lisacek F, Tiemeyer M, Mazumder R, Aoki-Kinoshita KF. JACS Au. 2022 Dec 2; 3(1): 4-12. doi: 10.1021/jacsau.2c00477.
PMID: 36711080; PMCID: PMC9875223.
2022.12 新型うつ傾向とネット依存・デジタル認知症傾向との関連の縦断分析
坂部創一,山崎秀夫. 環境情報科学学術研究論文集.36: 167-172.
2022.12 Changes of signaling molecules in the axotomized rat facial nucleus.
Ishijima T, Nakajima K. J Chem Neuroanat. 2022 Dec; 126: 102179( 12 pages). doi: 10.1016/j.jchemneu.2022.102179. PMID: 36341893.
2022.09.27 Morphological difference of Escherichia coli non-heme ferritin iron cores reconstituted in the presence and absence
of inorganic phosphate.

Kuwata T, Sato D, Yanagida Y, Aoki E, Fujiwara K, Yoshimura H, Ikeguchi M. J Biol Inorg Chem. 2022 Sep; 27(6): 583-594. doi: 10.1007/s00775-022-01952-5.PMID: 35986810.
2022.09.27 Non-linear disulphide-centred S-shaped oligomers with inner and outer spacers connected by aromatic azo moieties.
Yap PW, Osman F, Yeap GY, Nakamura Y, Kaneko K, Shimizu A, Ito MM. Liquid Crystals. 2023; 50(3): 379-392. https://doi.org/10.1080/02678292.2022.2127161.
2022.09.14 Meeting report on the international symposium on microbial Glycoconjugates and the GlySpace alliance: from micro- to macroglycoscience (MiGGA symposium)
Hosoda M, Aoki K, Guerardel Y, Yamada I, Aoki-Kinoshita KF. Glycobiology. 2022 Nov 22; 32(12): 1066-1067. doi: 10.1093/
glycob/cwac062. PMID: 36103332.
2022.08.25 糖鎖遺伝子発現情報からの糖鎖構造推定ツールGlycoMapleの開発
細田正恵,木下聖子,藤田盛久. Journal of Japanese Biochemical Society. 2022; 94(4): 623-628.
2022.08 Cortical nicotinic enhancement of tone-evoked heightened activities and subcortical nicotinic enlargement of activated areas in mouse auditory cortex.
Nakanishi M, Nemoto M, Kawai HD. Neuroscience Research. 2022 Aug; 181: 55-65. doi: 10.1016/j.neures.2022.04.001. PMID: 35381300.
2022.07.28 Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9)
Honda T, Kawasaki N, Yanagihara R, Tamura R, Murakami K, Ichimiya T, Matsumoto N, Nishihara S, Yamamoto K. PLoS One. 2022 Jul 28;17(7):e0268485. doi:10.1371/journal.pone.0268485. PMID: 35901072; PMCID: PMC9333281.
2022.07.28 Regularizing self-attention on vision transformers with 2D spatial distance loss.
Mormille, L.H., Broni-Bediako, C. & Atsumi, M. Artificial Life and Robotics. 2022; 27(3):586-593.
2022.07.02 Turkeys possess diverse Siaα2-3Gal glycans that facilitate their dual susceptibility to avian influenza viruses isolated from ducks and chickens.
Kobayashi D, Hiono T, Ichii O, Nishihara S, Takase-Yoden S, Yamamoto K, Kawashima H, Isoda N, Sakoda Y. Virus Res. 2022 Jul 2; 315: 198771. doi:10.1016/j.virusres.2022.198771. PMID: 35429616.
2022.06.29 Events Occurring in the Axotomized Facial Nucleus.
Nakajima K, Ishijima T. Cells. 2022 Jun 29; 11(13): 2068(30 pages). doi: 10.3390/cells11132068. PMID: 35805151; PMCID: PMC9266054.
2022.06.26 Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina.
Abdullah A, Hayashi Y, Morimura N, Kumar A, Ikenaka K, Togayachi A, Narimatsu H, Hitoshi S. Neurochem Res. 2022 Sep; 47(9): 2793-2804. doi: 10.1007/s11064-022-03651-8. PMID: 35753011.
2022.06.23 Glycoproteomics.
Bagdonaite I, Malaker SA, Polasky DA, Riley NM, Schjoldager K, Vakhrushev SY, Halim A, Aoki-
Kinoshita KF, Nesvizhskii AI, Bertozzi CR, Wandall HH, Parker BL, Thaysen-Andersen M, Scott NE. Nat Rev Methods Primers. 2022; 2: 1-29. PMID: 35696078.
2022.06.14 Functions of Glycosylation and Related Web Resources for Its Prediction.
Aoki-Kinoshita KF. Methods in molecular biology (Clifton, N.J.). 2022; 2499: 135-144. doi: 10.1007/978-1-0716-2317-6_6.
PMID: 35696078.
2022.06.13 CarbArrayART: a new software tool for carbohydrate microarray data storage, processing, presentation, and reporting.
Akune Y, Arpinar S, Silva LM, Palma AS, Tajadura-Ortega, V, Aoki-Kinoshita KF, Ranzinger R, Liu Y, Feizi T. Glycobiology. 2022 Jun 13; 32(7): 552-555. doi: 10.1093/glycob/cwac018. PMID: 35352122; PMCID: PMC9191619.
2022.05.23 Disaccharide-tag for highly sensitive identification of O-GlcNAc-modified proteins in mammalian cells
Abo H, Kume M, Pecori F, Miura T, Matsumoto N, Nishihara S, Yamamoto K. PLoS One. 2022 May 23;17(5):e0267804. doi: 10.1371/journal.pone.0267804. PMID: 35604954; PMCID: PMC9126400.
2022.05.08 Computational Modeling of O-Linked Glycan Biosynthesis in CHO Cells.
Kouka T, Akase S, Sogabe I, Jin C, Karlsson NG, Aoki-Kinoshita, K.F. Molecules( Basel, Switzerland). 2022 Mar 8; 27(6): 1766. doi: 10.3390/molecules27061766. PMID: 35335136; PMCID: PMC8950484.
2022.04.22 GALAXY ver3: updated web application for glycosylation profiling based on 3D HPLC map
Yagi H, Amagasa E, Shiota M, Yamada I, Aoki-Kinoshita KF, Kato K. Glycobiology. 2022 Jul 13; 32(8): 646-
650. doi: 10.1093/glycob/cwac025. PMID: 35452093.
2022.01.05 Development of a novel monosaccharide substitution matrix for improved comparison of glycan structures.
Fujita, A, Aoki-Kinoshita, K.F. Carbohydrate research. 2022 Jan; 511: 108496. doi:10.1016/j.carres.2021.108496. PMID: 35030433.
2021.12.02 DeepNGlyPred: A Deep Neural Network-Based Approach for Human N-Linked Glycosylation Site Prediction.
Pakhrin SC, Aoki-Kinoshita KF, Caragea D, Kc DB. Molecules. 2021 Dec 2;26(23):7314. doi: 10.3390/molecules26237314. PMID: 34885895; PMCID: PMC8658957.
2021.11.25 SugarDrawer: A Web-Based Database Search Tool with Editing Glycan Structures.
Tsuchiya S, Matsubara M, Aoki-Kinoshita KF, Yamada I. Molecules. 2021 Nov 25;26(23):7149. doi: 10.3390/molecules26237149. PMID: 34885724; PMCID: PMC8659005.
2021.11.22 RDFizing the biosynthetic pathway of E.coli O-antigen to enable semantic sharing of microbiology data.
Lee S, Ono T, Aoki-Kinoshita K. BMC Microbiol. 2021 Nov 22;21(1):325. doi: 10.1186/s12866-021-02384-y. PMID: 34809564; PMCID: PMC8607589.
2021.10.18 Functional glyco-metagenomics elucidates the role of glycan-related genes in environments.
Takihara H, Miura N, Aoki-Kinoshita KF, Okuda S. BMC Bioinformatics. 2021 Oct 18;22(1):505. doi: 10.1186/s12859-021-04425-9. PMID: 34663219; PMCID: PMC8522060.
2021.09.23 Dermatan-4-O-Sulfotransferase-1 Contributes to the Undifferentiated State of Mouse Embryonic Stem Cells
Ogura C, Nishihara S. Front Cell Dev Biol. 2021 Sep 23;9:733964. doi: 10.3389/fcell.2021.733964. PMID: 34631712; PMCID: PMC8495257.
2021.09.09 GlycoBioinformatics
Aoki-Kinoshita KF, Lisacek F, Karlsson N, Kolarich D, Packer NH. Beilstein J Org Chem. 2021 Nov 9;17:2726-2728. doi: 10.3762/bjoc.17.184. PMID: 34858527; PMCID: PMC8593694.
2021.07.13 Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis.
Pecori F, Kondo N, Ogura C, Miura T, Kume M, Minamijima Y, Yamamoto K, Nishihara S. Cell Rep. 2021 Jul 13;36(2):109361. doi: 10.1016/j.celrep.2021.109361. PMID: 34260942.
2021.06.25 Sulfated glycans containing NeuAcα2-3Gal facilitate the propagation of human H1N1 influenza A viruses in eggs.
Ichimiya T, Okamatsu M, Kinoshita T, Kobayashi D, Ichii O, Yamamoto N, Sakoda Y, Kida H, Kawashima H, Yamamoto K, Takase-Yoden S, Nishihara S. Virology. 2021 Jun 25;562:29-39. doi: 10.1016/j.virol.2021.06.008. Epub ahead of print. PMID: 34246113.
2021.06.01 Glycome informatics: using systems biology to gain mechanistic insights into glycan biosynthesis.
Aoki-Kinoshita, K. Current opinion in chemical engineering 32 (2021): 100683.
https://doi.org/10.1016/j.coche.2021.100683
2021.04.19 Global mapping of glycosylation pathways in human-derived cells.
Huang YF, Aoki K, Akase S, Ishihara M, Liu YS, Yang G, Kizuka Y, Mizumoto S, Tiemeyer M, Gao XD, Aoki-Kinoshita KF, Fujita M. Dev Cell. 2021 Apr 19;56(8):1195-1209.e7. doi: 10.1016/j.devcel.2021.02.023. Epub 2021 Mar 16. PMID: 33730547; PMCID: PMC8086148.
2021.02.06 Dermatan sulphate promotes neuronal differentiation in mouse and human stem cells.
Ogura C, Hirano K, Mizumoto S, Yamada S, Nishihara S. J Biochem. 2021 Feb 6;169(1):55-64. doi: 10.1093/jb/mvaa087. PMID: 32730567.
2021.01.14 A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition.
Pecori F, Yokota I, Hanamatsu H, Miura T, Ogura C, Ota H, Furukawa JI, Oki S, Yamamoto K, Yoshie O, Nishihara S. Sci Rep. 2021 Jan 14;11(1):1276. doi: 10.1038/s41598-020-79666-4. PMID: 33446700; PMCID: PMC7809059.
2021.01.08 GlycoPOST realizes FAIR principles for glycomics mass spectrometry data.
Watanabe Y, Aoki-Kinoshita KF, Ishihama Y, Okuda S. Nucleic Acids Res. 2021 Jan 8;49(D1):D1523-D1528. doi: 10.1093/nar/gkaa1012. PMID: 33174597; PMCID: PMC7778884.
2021.01.08 The international glycan repository GlyTouCan version 3.0.
Fujita A, Aoki NP, Shinmachi D, Matsubara M, Tsuchiya S, Shiota M, Ono T, Yamada I, Aoki-Kinoshita KF. Nucleic Acids Res. 2021 Jan 8;49(D1):D1529-D1533. doi: 10.1093/nar/gkaa947. PMID: 33125071; PMCID: PMC7779025.
2020.10.27 A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR).
Kellman BP, Zhang Y, Logomasini E, Meinhardt E, Godinez-Macias KP, Chiang AWT, Sorrentino JT, Liang C, Bao B, Zhou Y, Akase S, Sogabe I, Kouka T, Winzeler EA, Wilson IBH, Campbell MP, Neelamegham S, Krambeck FJ, Aoki-Kinoshita KF, Lewis NE. Beilstein J Org Chem. 2020 Oct 27;16:2645-2662. doi: 10.3762/bjoc.16.215. PMID: 33178355; PMCID: PMC7607430.
2020.10.23 Mucin-type O-glycosylation controls pluripotency in mouse embryonic stem cells via Wnt receptor endocytosis.
Pecori F, Akimoto Y, Hanamatsu H, Furukawa JI, Shinohara Y, Ikehara Y, Nishihara S. J Cell Sci. 2020 Oct 23;133(20):jcs245845. doi: 10.1242/jcs.245845. PMID: 32973111
2020.07.17 The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences.
Yamada I, Shiota M, Shinmachi D, Ono T, Tsuchiya S, Hosoda M, Fujita A, Aoki N.P, Watanabe Y, Fujita N, Angata K, Kaji H, Narimatsu H, Okuda S, Aoki-Kinoshita K.F. Nat Methods. 2020 Jul;17(7):649-650. doi: 10.1038/s41592-020-0879-8. PMID: 32572234
2020.06.01 GlyGen data model and processing workflow.
Kahsay R, Vora J, Navelkar R, Mousavi R, Fochtman BC, Holmes X, Pattabiraman N, Ranzinger R, Mahadik R, Williamson T, Kulkarni S, Agarwal G, Martin M, Vasudev P, Garcia L, Edwards N, Zhang W, Natale DA, Ross K, Aoki-Kinoshita KF, Campbell MP, York WS, Mazumder R. Bioinformatics. 2020 Jun 1;36(12):3941-3943. doi: 10.1093/bioinformatics/btaa238. PMID: 32324859; PMCID: PMC7320628.
2020.04.16 E190V substitution of H6 hemagglutinin is one of key factors for binding to sulfated sialylated glycan receptor and infection to chickens.
Kikutani Y, Okamatsu M, Nishihara S, Takase-Yoden S, Hiono, T, de Vries R, McBride R, Matsuno K, Kida H, Sakoda Y. Microbiol. Immunol. 2020 Apr;64(4):304-312. doi: 10.1111/1348-0421.12773. Epub 2020 Feb 5. PMID: 31943329.
2020.02 Functional analysis of glycosylation using Drosophila melanogaster.
Nishihara S. Glycoconj J. 2020 Feb;37(1):1-14. doi: 10.1007/s10719-019-09892-0. Epub 2019 Nov 26. PMID: 31773367.
2020.01.28 GlyGen: Computational and Informatics Resources for Glycoscience.
York WS, Mazumder R, Ranzinger R, Edwards N, Kahsay R, Aoki-Kinoshita KF, Campbell MP, Cummings RD, Feizi T, Martin M, Natale DA, Packer NH, Woods RJ, Agarwal G, Arpinar S, Bhat S, Blake J, Castro LJG, Fochtman B, Gildersleeve J, Goldman R, Holmes X, Jain V, Kulkarni S, Mahadik R, Mehta A, Mousavi R, Nakarakommula S, Navelkar R, Pattabiraman N, Pierce MJ, Ross K, Vasudev P, Vora J, Williamson T, Zhang W. Glycobiology. 2020 Jan 28;30(2):72-73. doi: 10.1093/glycob/cwz080. PMID: 31616925; PMCID: PMC7335483.
2020.01.28 The GlySpace Alliance: toward a collaborative global glycoinformatics community.
Aoki-Kinoshita KF, Lisacek F, Mazumder R, York WS, Packer NH. Glycobiology. 2020 Jan 28;30(2):70-71. doi: 10.1093/glycob/cwz078. PMID:31573039; PMCID: PMC6992953.
2019.10.20 Highly sulfated hyaluronic acid maintains human induced pluripotent stem cells under feeder-free and bFGF-free conditions.
Miura T, Yuasa N, Ota H, Habu M, Kawano M, Nakayama F, Nishihara S. Biochem Biophys Res Commun. 2019 Oct 20;518(3):506-512. doi: 10.1016/j.bbrc.2019.08.082. Epub 2019 Aug 19. PMID: 31439376
2019.08.20 Updates to the Symbol Nomenclature for Glycans guidelines.
Neelamegham S, Aoki-Kinoshita K, Bolton E, Frank M, Lisacek F, Lütteke T, O'Boyle N, Packer NH, Stanley P, Toukach P, Varki A, Woods RJ; SNFG Discussion Group. Glycobiology. 2019 Aug 20;29(9):620-624. doi: 10.1093/glycob/cwz045. PMID: 31184695; PMCID: PMC7335484.
2019.08.15 LM-GlycomeAtlas Ver. 1.0: A Novel Visualization Tool for Lectin Microarray-Based Glycomic Profiles of Mouse Tissue Sections.
Nagai-Okatani C, Aoki-Kinoshita KF, Kakuda S, Nagai M, Hagiwara K, Kiyohara K, Fujita N, Suzuki Y, Sato T, Angata K, Kuno A. Molecules. 2019 Aug 15;24(16):2962. doi: 10.3390/molecules24162962. PMID: 31443278; PMCID: PMC6719194.
2019.07.22 Towards a standardized bioinformatics infrastructure for N- and O-glycomics.
Rojas-Macias MA, Mariethoz J, Andersson P, Jin C, Venkatakrishnan V, Aoki NP, Shinmachi D, Ashwood C, Madunic K, Zhang T, Miller RL, Horlacher O, Struwe WB, Watanabe Y, Okuda S, Levander F, Kolarich D, Rudd PM, Wuhrer M, Kettner C, Packer NH, Aoki-Kinoshita KF, Lisacek F, Karlsson NG. Nat Commun. 2019 Jul 22;10(1):3275. doi: 10.1038/s41467-019-11131-x. PMID: 31332201; PMCID: PMC6796180.
2019.07.15 Cell Profiling Based on Sugar-Chain-Cell Binding Interaction and Its Application to Typing and Quality Verification of Cells.
Shinchi H, Nakamura T, Ota H, Nishihara S, Wakao M, Suda Y. Chembiochem. 2019 Jul 15;20(14):1810-1816. doi: 10.1002/cbic.201900028. Epub 2019 May 21. PMID: 30816597.
2019.07.15 presentation of a paper
GlycanFormatConverter: a conversion tool for translating the complexities of glycans.
Tsuchiya S, Yamada I, Aoki-Kinoshita KF. Bioinformatics. 2019 Jul 15;35(14):2434-2440. doi: 10.1093/bioinformatics/bty990. PMID: 30535258; PMCID: PMC6612873.

Invited Lectures

List of invited lectures by GaLSIC members.

2023.03.12-17 Nishihara S. Glycosylation regulates pluripotent stem cell status and signaling. Glycobiology Gordon Research Conference. Ventura, United States.
2022.12.07 Aoki-Kinoshita KF. Informatic infrastructure for the glycosciences to enhance computational life
sciences. HUPO 2022. Cancun, Mexico.
2022.11.25 Aoki-Kinoshita KF. Using inference on Semantic Web data to enrich the data in GlyCosmos. 4th AGS
Meeting & 9th Warren Workshop, Gold Coast, Australia.
2022.11.17 Aoki-Kinoshita KF. Expansion of the GlyCosmos Portal with disease and microbial data. Society for
Glycobiology Annual Meeting, Online.
2022.09.07 Aoki-Kinoshita KF. Integration of data surrounding sialic acids through the GlyCosmos Portal.
Sialoglyco2022. Nagoya
2022.07.10-15 Nishihara S. Biological roles of glycans in stem cells. The 30th International Carbophydrate Symposium. Online, Brazil.
2019.12.04-06 Shoko Nishihara, Taichi Miura, Hayato Ota, Noriyuki Yuasa, Masato Habu, Federico Pecori, Fumiaki Nakayama, Chika Ogura
Function of glycans in pluripotent stem cells
1st International Symposium on Glycans', Zhuhai, China,2019-12-04 to 2019-12-06
2019.11.11-14 Shoko Nishihara, Taichi Miura, Hayato Ota, Noriyuki Yuasa, Masato Habu, Federico Pecori, Fumiaki Nakayama, Chika Ogura
Functional analyses of glycans in mammalian stem cells
11th Asian Community of Glycoscience and Glycotechnology Conference, November 11-14, 2019 (Busan, Korea) Invited
2019.09.18-20 Nishihara Shoko:Heparan sulfate and O-GlcNAc modification regulate signaling in pluripotent stem cells.
The 92nd Annual Meeting of Japanese Biochemical Society, Yokohama.
2019.08.25-41 Nishihara S: Functional analysis of mucin-type O-glycans using Drosophila melanogaster
the 25th International Symposium on Glycoconjugates (GLYCO XXV), August 25- 31, 2019, Milano, Italy, Invited
2019.08.19-21 invited lecture
西原祥子:糖鎖領域とあらゆる生命科学領域の融合と相互理解、第38回日本質学会年会、名古屋大学豊田講堂(招待講演)

Symposia

List of symposia, workshops, etc. organized by GaLSIC members.

2022.11.30-12.02 Nishihara Shoko.「Intractable and rare diseases related to glycans: From basic to diagnosis and treatment - Introduction. The 45th Annual Meeting of the Molecular Biology Society of Japan, Makuhari Messe, Chiba
2022.11.30-12.02 Tadashi Kaname, Hayato Ohta, Kumiko Yanagi, Hisatoshi Hanamatsu, Federico Pecori, Junichi Furukawa, Yoshiki Yamaguchi, Tomoko Uehara, Jinichi Inokuchi, Kiyoko AokiKinoshita, Akira Togayachi, Kazuhito Satou,Shoko Nishihara. 「Genes to diagnosis and therapy in glycogenomics disorders: The example of GDP-fucose transporter deficiency, a rare disease」.The 45th Annual Meeting of the Molecular Biology Society of Japan, Makuhari Messe, Chiba
2022.11.30-12.02 Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Aoki Taiga, Junichi Furukawa, Akira Togayachi, Kiyoko Aokikinoshita, Junichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, Yoshiki Yamaguchi, Shoko Nishihara. 「A new method for diagnosis and predicting X-linked recessive brachytelephalangic chondrodysplasia punctata: Computational analysis and identification of novel missense mutation」. The 45th Annual Meeting of the Molecular Biology Society of Japan, Makuhari Messe, Chiba
2022.09.28-30 Nishihara Shoko. Site-specific O-GlcNAcylation of Psme3 maintains mouse embryonic stem cell pluripotency by impairing P-body homeostasis. The 60th Annual Meeting of the Biophysical Society of Japan, Hokkaido.
2022.09 細田正恵. 医療から環境まで広がる糖鎖の世界へ. 2022年日本バイオインフォマティクス学会年会・第11 回生命医薬情報学連合大会 (IIBMP2022)、大阪
2022.08 宮下正明,篠宮紀彦,笠松大佑,石垣原野.複数ラウンドの情報提供によるOSN 外行動者数の最大化.
電子情報通信学会 第35 回回路とシステムワークショップ.D2-2,pp. 185-190.
2022.08 福田秀太,篠宮紀彦.Machine Learning を用いた端末の基地局割り当て最適化に関する研究.電子情
報通信学会 第35 回回路とシステムワークショップ.D1-3,pp. 173-178.
2022.08 東松一真,大濱開,笠松大佑.分散ストリーム処理における適応パーティショニング手法.第35 回回
路とシステムワークショップ.pp. 255-256. 福岡県
2022.03.01-03 International Symposium on Microbial Glycoconjugates and the GlySpace Alliance:from micro to macro glycoscience (MiGGA).
Organizers:Kiyoko F. Aoki-Kinoshita (GaLSIC, Japan), Kazuhiro Aoki (CCRC, University of Georgia, USA), Yann Guerardel (Lille University, France), Issaku Yamada (The Noguchi Institute, Japan), Masae Hosoda (GaLSIC, Japan) Online event.
2019.09.18-20 hosting a symposium
Glycans regulate signaling(Symposium 1S10a)
Organizers:Satomi Nadanaka (Kobe Pharmaceutical University), Nishihara Shoko(Soka University)
The 92nd Annual Meeting of The Japanese Biochemical Society, Yokohama.

Others Activities

List of special invited conference and research achievements by the faculty members.

2019.11.18-19 Other Research Achievements
インフルエンザウイルスの宿主間伝播に関わる新規分子機構の解明.
岡松正敏、高瀬 明、西原祥子.国立研究開発法人日本医療研究開発機構(AMED)感染症研究革新イニシアティブ(J-PRIDE)研究成果発表会「重症・難治性感染症の理解と予防・治療法の開発に向けて〜若手研究者たちの挑戦〜」(公開)2019年11月18-19日(東京、イイノホール)

GaLSIC's Annual Reports

Annual Research Reports are listed as follows.

Close

Access

Location / Contact Information

Postal Code: 192-8577
Address: 1-236 Tangi-machi, Hachioji-shi, Tokyo
Soka University Glycan and Life System Integration Center Administration Office (Faculty of Engineering Administration Office)
TEL: 042-691-9400
FAX: 042-691-9311
Email: galsic★≡soka.ac.jp (please replace ★≡ with @)

LANGUAGE