Professor
Masamichi Ikeguchi

Profile
Specialized field | Biomolecular science, structural biochemistry, biophysics |
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Research theme | Elucidation of protein folding mechanisms |
Subjects in charge | Introduction to Physics, Enzyme Chemistry, Quantum Chemistry, Structural Biology, Structural Information Biology, Protein Engineering, Biotechnology, General Overview of Science and Engineering, Topics in Advanced Science and Engineering, Case Studies I and II, Seminars I and II |
Specialized field | Protein design, structural information biology |
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Research theme | It is known that the three-dimensional structure of a protein is determined by its amino acid sequence. Therefore, it should be possible to predict the three-dimensional structure from the amino acid sequence and to design artificial proteins, but the technology has not yet been established. We are investigating the reaction by which the three-dimensional structure of a protein is formed (folding) using physicochemical methods such as the stopped-flow method and NMR, and by exploring how the folding reaction changes when the amino acid sequence of a protein is changed by genetic recombination technology, we aim to learn the principles of protein three-dimensional structure construction and to develop technology to predict the three-dimensional structure from the amino acid sequence and to design artificial proteins. |
Subjects in charge | Introduction to Physics, Quantum Chemistry, Structural Biology, Protein Engineering |
Main career, work history, and academic background | 1988 Completed doctoral course at Hokkaido University Graduate School, Doctor of Science |
Affiliated academic societies and organizations | Japanese Biochemical Society Biophysical Society of Japan Molecular Biology Society of Japan Protein Science Society of Japan Japan Society for Nuclear Magnetic Resonance Society of Polymer Science The Protein Society (USA) |
Main Papers and Publications | "A physicochemical and mutational analysis of intersubunit interactions of Escherichia coli ferritin A" |
Specialized field | Biomolecular science, structural biochemistry, biophysics |
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Research theme | Elucidation of protein folding mechanisms |