Shinsaku Maruta

Biochemistry, Biophysics, Bionanotechnology

(1) Research on the mechanism of muscle contraction at the molecular level: We are analyzing at the molecular level how the chemical energy of ATP is converted into mechanical contractile motion.
(2) Research into the energy conversion mechanism of kinesin, a molecular motor in living organisms that uses the chemical energy of ATP to move.
(3) Development of light-driven and light-controlled biomolecular machines using photochromic molecules
(4) Study on the structure and function of molecular motors in the higher plant rice
(5) Application of liposomes with photoresponsive channel mechanisms to drug delivery systems

Biochemistry I, Biophysical Chemistry, Biochemistry Lab, Biomaterial Analytical Chemistry Lab

Born in Kagoshima Prefecture in 1959
1982 Graduated from Nagasaki University, Faculty of Engineering, Department of Applied Chemistry
1984: Nagasaki University Graduate School Master's Degree (Master of Pharmacy)
1988 Completed doctoral course at Nagasaki University Graduate School (Doctor of Medicine)
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1988 Case Western Reserve University School of Medicine, USA
Postdoctoral Researcher, Department of Physiology and Biophysics
1991: Assistant Professor, Faculty of Engineering, Soka University
1995 Lecturer at the Faculty of Engineering, Soka University
1999: Assistant Lecturer Faculty of Engineering, Soka University
2005 Professor, Faculty of Engineering, Soka University

Japanese Biochemical Society
Biophysical Society of Japan
Molecular Biology Society of Japan
American Biophysical Society
American Society for Biochemistry and Molecular Biology
American Society for Cell Biology

(1) "Formation of the Stable Myosin-ADP-Aluminium Fluoride and Myosin-ADP-Beryllium Fluoride Complexes and their analysis using 19F-NMR" Maruta, S., Henry, G. D., Sykes, B. D. & Ikebe, M. (1993) J. Biol. Chem.
268, 7093 - 7100.
(2) "Photoaffinitylabelling of smooth Muscle Myosin by Methylanthraniloyl-8-azido-ATP" Maruta, S. & Ikebe, M. (1993) Biochemical Journal 292, 439-444.
(3) "Observation of Multiple Myosin Subfragment-1:ADP:Fluoroberyllate Complexes by 19F-NMR" Henry, G. D., Maruta, S., Ikebe, M., & Sykes, B. D. (1993) Biochemistry 32, 10451-10456.
(4) "Analysis of stress in the active site of myosin accompanied by conformational changes in transient state intermediate complexes using photoaffinity labeling anf 19F-NMR" Maruta, S., Henry, G. D., Ohki, T., Kambara, T., Sykes, B. D., & Ikebe, M.(1998) Eur. J. Biochem. 252, 520-529.
(5) "Characterization of the interaction of myosin with ATP analogues having synconformation with respect to the adenine-ribose bond" Maruta, S., Ohki, T., Kambara, T., & Ikebe, M. (1998) Eur. J. Biochem.
256, 229-237.
(6) "A unique loop contributing to the structure of the ATP binding cleft of skeletal muscle myosin communicates 　with the actin binding site" Maruta, S., & Homma, K.(1998) J. Biochem. 124, 528-533.
(7) "Interaction of a new fluorescent ATP analogue with skeletal muscle myosin subfragment-1" Maruta, S., Mizukura, Y., & Chaen, S. (2002) J. Biochem. 131, 905-911.
(8) "Determination of human myosin III as a motor protein having a protein kinase activity " Komaba, S., Inoue, A., Maruta, S., Hosoya, H., & Ikebe, M. (2003) J. Biol. Chem. 278,　21352-21360.

Japan Society for the Promotion of Science International Joint Research (Japanese Principal Investigator) Japan-Canada/USA (1994-1995)
(Awards)
American Heart Association Post-doctral fellowship (1990-1991)