高瀬 明(教授)

タカセ サヤカ

専門分野 ウイルス学
担当科目 微生物学、微生物学実験、免疫科学、ケーススタディⅠ・Ⅱ、演習Ⅰ・Ⅱ
研究テーマ 1.レトロウイルスおよびインフルエンザウイルスの感染開始機構の解明
2.レトロウイルスの遺伝子発現制御機構の解明
3.マウス白血病ウイルスの神経病原性に関わる遺伝子領域とその役割の解明

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研究者情報詳細

工学研究科 生命情報工学専攻

  • 専門分野 ウイルス学
    担当科目 免疫科学、微生物、微生物学実習
    研究テーマ ウイルスの感染開始機構および遺伝子発現機構の分子基盤
    1.マウス白血病ウイルスおよびインフルエンザウイルスと細胞表面分子との相互作用の解析
    2.マウス白血病ウイルス遺伝子発現の転写後調節機構の解明
    3.マウス白血病ウイルスの神経病原性に関わる遺伝子領域とその役割の解明
    略歴 1957年 兵庫県生まれ
    1987年 北海道大学大学院獣医学研究科 博士課程 修了
          獣医学博士
    ------------------------------------------------
    英国NERC, Institute of Virology の博士研究員および国立精神・神経センター神経研究所の研究員を経て
    1991年 創価大学生命科学研究所 免疫科学部門 講師
    1997年 創価大学生命科学研究所 免疫科学部門 助教授
    2001年 創価大学生命科学研究所 免疫科学部門 教授
    2003年 創価大学工学部 生命情報工学科 教授
    主な著書論文 原著論文 (2006〜2014)
    Machinaga A, Takase-Yoden S (2014) A 38 nt region and its flanking sequences within gag of Friend murine leukemia virus are crucial for splicing at the correct 5' and 3' splice sites. Microbiol. Immunol. 58, 38-50.
    Hiono T, Okamatsu M, Nishihara S, Takase-Yoden S, Sakoda Y, Kida H (2014) A chicken influenza virus recognizes fucosylated α2,3 sialoglycan receptors on the epithelial cells lining upper respiratory tracts of chickens. Virology 456-457, 131–138
    Machinaga A, Takase‐Yoden S (2014) Polyadenylation of Friend murine leukemia virus env-mRNA is affected by its splicing. Microbiol. Immunol. 58, 474–482.
    Ichimiya T, Nishihara S, Takase-Yoden S, Kida H, Aoki-Kinoshita KF (2014) Frequent glycan structure mining of influenza virus data revealed a sulfated glycan motif that increased viral infection. Bioinformatics 30, 706–711.
    Choo YC, Seki Y, Machinaga A, Ogita N, Takase-Yoden S (2013) The 0.3-kb fragment containing the R-U5-5’leader sequence of Friend murine leukemia virus influences the level of protein expression from spliced mRNA. Virol. J. 10:124
    Choo YC, Seki Y, Takase-Yoden S (2013) Kinetic studies of the effect of a 17 nucleotide difference in the 0.3 kb region containing the R-U5-5’ leader sequence of Friend murine leukemia virus on viral gene expression. Microbiol. Immunol. 57, 594–599.
    Seki, Y., Mizukura, M., Ichimiya, T., Suda, Y., Nishihara, S., Masuda, M., and Takase-Yoden, S. (2012) O-Sulfate Groups of Heparin are Critical for Inhibition of Ecotropic Murine Leukemia Virus Infection by Heparin. Virology 424, 56-66.
    Seki, Y., Hirano, N., Mizukura, M., Watanabe, R., and Takase-Yoden, S. (2011) Narrowing down the critical region within env gene for determining neuropathogenicity of murine leukemia virus A8. Microbiol. Immunol. 55, 694-703.
    Yamamoto, N., and Takase-Yoden, S. (2009) Analysis of cis-regulatory elements in the 5’ Untranslated region of murine leukemia virus controlling protein expression. Microbiol. Immunol. 53, 140-148.
    Yamamoto, N., and Takase-Yoden, S. (2009) Friend murine leukemia virus A8 regulates Env protein expression through an intron sequence. Virology 385, 115–125.
    Takase-Yoden, S., Wada, M., and Watanabe, R. (2006) A Viral non-coding region determining neuropathogenicity of murine leukemia virus A8 is responsible for envelope protein expression in the rat brain. Microbiol. Immunol. 50, 197-201.
    Watanabe, R. and Takase-Yoden, S. (2006) Neuropathology induced by infection with Friend murine leukemia viral clone A8-V depends upon the level of viral antigen expression. Neuropathology 26,188-195.
    Kanamatsu, T., Watanabe, R., and Takase-Yoden, S. (2006) Cerebral metabolism in brains of rats infected with neuropathogenic murine leukemia viruses. J. Vet. Med. Sci. 68, 259-265.
    原著論文(1999〜2005)
    Takase-Yoden, S. and Watanabe, R. (2005) A 0.3 kb fragment containing the R-U5-5' leader sequence is essential for the induction of spongiform neurodegeneration by A8 murine leukemia virus. Virology, 336, 1-10.
    Hirano, T., Watanabe, R. and Takase-Yoden, S. (2005) Increased expression of c-myc is associated with thymoma in rats infected with murine leukemia virus A8. Microbiol. Immunol. 49, 1069-1074.
    Nakai, R., Takase-Yoden, S., and Watanabe, R. (2005) Analysis of the distribution of neuropathogenic retroviral antigens following PVC211 or A8-V infection. Microbiol. Immunol. 49, 1075-1081.
    Yamakawa. K., Takase-Yoden, S., and Watanabe, R. (2005) Interruption of env gene expression depending on the length of the SV40 early region used for the polyA signal. Jpn. J. Infect. Dis. 58, 380-382.
    Takase-Yoden, S. and Watanabe, R. (2004) Unique three-repeat sequences containing FVa, LVb/C4, and CORE motifs in LTR-U3 of friend murine leukemia virus clone A8 accelerate the induction of thymoma in rat. Virology, 326, 29-40.
    Fukumitsu, H., Takase-Yoden, S., Furukawa, S., Nemoto, K., Ikeda, T., and Watanabe, R. (2002) Implantation of BDNF producing packaging cells into brain. Cell Transplant. 11, 459-464.
    Takase-Yoden, S. and Watanabe, R. (2002) Identification of genetic determinants that regulate tumorigenicity of Friend murine leukemia virus in rats. Microbiol. Immunol. 46, 885-890.
    Watanabe, R., Takase-Yoden, S., Fukumitsu, H., and Nakajima, K.(2002) Cell transplantation to the brain with microglia labeled by neuropathogenic retroviral vector system. Cell Transplant. 11, 471-473.
    Takase-Yoden,S. and Watanabe, R. (2001) Distribution of ecotropic retrovirus receptor protein in rat brains detected by immunohistochemistry.J. Gen. Virol. 82, 1815-1820.
    Ikeda, H., Kato, K., Suzuki, T., Kitani, H., Matsubara, Y., Takase-Yoden, S., Watanabe, R., Kitagawa, M., and Aizawa, S. (2000) Properties of the naturally occurring soluble SU protein of ecotropic MuLV: Binding specificity and possible conformational change after binding to receptor.J. Virol. 74, 1815-1826.
    Takase-Yoden,S. and Watanabe, R. (1999) Contribution of virus-receptor interaction to distinct viral proliferation of neuropathogenic and nonneuropathogenic murine leukemia virus in rat glial cells. J. Virol. 73, 4461-4464.
    Takase-Yoden,S. and Watanabe, R. (1999) High incidence of meningeal infiltration by leukemic cells after infection of chimeric virus between neuropathogenic and nonneuropathogenic retroviruses. J. Neurovirol. 5, 414-420.
    総説
    渡辺里仁、高瀬(余田)明 (2005) 神経病原性マウスレトロウイルス感染による海綿状脳症. 神経免疫学 13, 247-253.
    Takase-Yoden, S. and Watanabe, R. (2003) Role of glial cells in neuropathogenesis of murine leukemia viruses. Current Topics in Virology 3, 119-124.
    所属学会 日本ウイルス学会
    日本獣医学会
    日本分子生物学会
    日本神経ウイルス研究会

ページ公開日:2017年08月07日
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