活動 | 糖鎖研究所

論文発表

2022.05.08	Computational Modeling of O-Linked Glycan Biosynthesis in CHO Cells. Kouka T, Akase S, Sogabe I, Jin C, Karlsson NG, Aoki-Kinoshita, K.F. Molecules. 2022 Mar 8;27(6):1766. doi: 10.3390/molecules27061766. PMID: 35335136; PMCID: PMC8950484.
2022.01.05	Development of a novel monosaccharide substitution matrix for improved comparison of glycan structures. Fujita, A, Aoki-Kinoshita, K.F. Carbohydr Res. 2022 Jan;511:108496. doi: 10.1016/j.carres.2021.108496. Epub 2022 Jan 4. PMID: 35030433.
2021.12.02	DeepNGlyPred: A Deep Neural Network-Based Approach for Human N-Linked Glycosylation Site Prediction. Pakhrin SC, Aoki-Kinoshita KF, Caragea D, Kc DB. Molecules. 2021 Dec 2;26(23):7314. doi: 10.3390/molecules26237314. PMID: 34885895; PMCID: PMC8658957.
2021.11.25	SugarDrawer: A Web-Based Database Search Tool with Editing Glycan Structures. Tsuchiya S, Matsubara M, Aoki-Kinoshita KF, Yamada I. Molecules. 2021 Nov 25;26(23):7149. doi: 10.3390/molecules26237149. PMID: 34885724; PMCID: PMC8659005.
2021.11.22	RDFizing the biosynthetic pathway of E.coli O-antigen to enable semantic sharing of microbiology data. Lee S, Ono T, Aoki-Kinoshita K. BMC Microbiol. 2021 Nov 22;21(1):325. doi: 10.1186/s12866-021-02384-y. PMID: 34809564; PMCID: PMC8607589.
2021.10.18	Functional glyco-metagenomics elucidates the role of glycan-related genes in environments. Takihara H, Miura N, Aoki-Kinoshita KF, Okuda S. BMC Bioinformatics. 2021 Oct 18;22(1):505. doi: 10.1186/s12859-021-04425-9. PMID: 34663219; PMCID: PMC8522060.
2021.09.09	GlycoBioinformatics Aoki-Kinoshita KF, Lisacek F, Karlsson N, Kolarich D, Packer NH. Beilstein J Org Chem. 2021 Nov 9;17:2726-2728. doi: 10.3762/bjoc.17.184. PMID: 34858527; PMCID: PMC8593694.
2021.07.13	Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis. Pecori F, Kondo N, Ogura C, Miura T, Kume M, Minamijima Y, Yamamoto K, Nishihara S. Cell Rep. 2021 Jul 13;36(2):109361. doi: 10.1016/j.celrep.2021.109361. PMID: 34260942.
2021.06.25	Sulfated glycans containing NeuAcα2-3Gal facilitate the propagation of human H1N1 influenza A viruses in eggs. Ichimiya T, Okamatsu M, Kinoshita T, Kobayashi D, Ichii O, Yamamoto N, Sakoda Y, Kida H, Kawashima H, Yamamoto K, Takase-Yoden S, Nishihara S. Virology. 2021 Jun 25;562:29-39. doi: 10.1016/j.virol.2021.06.008. Epub ahead of print. PMID: 34246113.
2021.06.01	Glycome informatics: using systems biology to gain mechanistic insights into glycan biosynthesis. Aoki-Kinoshita, K. Current opinion in chemical engineering 32 (2021): 100683. https://doi.org/10.1016/j.coche.2021.100683
2021.04.19	Global mapping of glycosylation pathways in human-derived cells. Huang YF, Aoki K, Akase S, Ishihara M, Liu YS, Yang G, Kizuka Y, Mizumoto S, Tiemeyer M, Gao XD, Aoki-Kinoshita KF, Fujita M. Dev Cell. 2021 Apr 19;56(8):1195-1209.e7. doi: 10.1016/j.devcel.2021.02.023. Epub 2021 Mar 16. PMID: 33730547; PMCID: PMC8086148.
2021.02.06	Dermatan sulphate promotes neuronal differentiation in mouse and human stem cells. Ogura C, Hirano K, Mizumoto S, Yamada S, Nishihara S. J Biochem. 2021 Feb 6;169(1):55-64. doi: 10.1093/jb/mvaa087. PMID: 32730567.
2021.01.14	A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition. Pecori F, Yokota I, Hanamatsu H, Miura T, Ogura C, Ota H, Furukawa JI, Oki S, Yamamoto K, Yoshie O, Nishihara S. Sci Rep. 2021 Jan 14;11(1):1276. doi: 10.1038/s41598-020-79666-4. PMID: 33446700; PMCID: PMC7809059.
2021.01.08	GlycoPOST realizes FAIR principles for glycomics mass spectrometry data. Watanabe Y, Aoki-Kinoshita KF, Ishihama Y, Okuda S. Nucleic Acids Res. 2021 Jan 8;49(D1):D1523-D1528. doi: 10.1093/nar/gkaa1012. PMID: 33174597; PMCID: PMC7778884.
2021.01.08	The international glycan repository GlyTouCan version 3.0. Fujita A, Aoki NP, Shinmachi D, Matsubara M, Tsuchiya S, Shiota M, Ono T, Yamada I, Aoki-Kinoshita KF. Nucleic Acids Res. 2021 Jan 8;49(D1):D1529-D1533. doi: 10.1093/nar/gkaa947. PMID: 33125071; PMCID: PMC7779025.
2020.10.27	A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR). Kellman BP, Zhang Y, Logomasini E, Meinhardt E, Godinez-Macias KP, Chiang AWT, Sorrentino JT, Liang C, Bao B, Zhou Y, Akase S, Sogabe I, Kouka T, Winzeler EA, Wilson IBH, Campbell MP, Neelamegham S, Krambeck FJ, Aoki-Kinoshita KF, Lewis NE. Beilstein J Org Chem. 2020 Oct 27;16:2645-2662. doi: 10.3762/bjoc.16.215. PMID: 33178355; PMCID: PMC7607430.
2020.10.23	Mucin-type O-glycosylation controls pluripotency in mouse embryonic stem cells via Wnt receptor endocytosis. Pecori F, Akimoto Y, Hanamatsu H, Furukawa JI, Shinohara Y, Ikehara Y, Nishihara S. J Cell Sci. 2020 Oct 23;133(20):jcs245845. doi: 10.1242/jcs.245845. PMID: 32973111
2020.07.17	The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences. Yamada I, Shiota M, Shinmachi D, Ono T, Tsuchiya S, Hosoda M, Fujita A, Aoki N.P, Watanabe Y, Fujita N, Angata K, Kaji H, Narimatsu H, Okuda S, Aoki-Kinoshita K.F. Nat Methods. 2020 Jul;17(7):649-650. doi: 10.1038/s41592-020-0879-8. PMID: 32572234
2020.06.01	GlyGen data model and processing workflow. Kahsay R, Vora J, Navelkar R, Mousavi R, Fochtman BC, Holmes X, Pattabiraman N, Ranzinger R, Mahadik R, Williamson T, Kulkarni S, Agarwal G, Martin M, Vasudev P, Garcia L, Edwards N, Zhang W, Natale DA, Ross K, Aoki-Kinoshita KF, Campbell MP, York WS, Mazumder R. Bioinformatics. 2020 Jun 1;36(12):3941-3943. doi: 10.1093/bioinformatics/btaa238. PMID: 32324859; PMCID: PMC7320628.
2020.04.16	E190V substitution of H6 hemagglutinin is one of key factors for binding to sulfated sialylated glycan receptor and infection to chickens. Kikutani Y, Okamatsu M, Nishihara S, Takase-Yoden S, Hiono, T, de Vries R, McBride R, Matsuno K, Kida H, Sakoda Y. Microbiol. Immunol. 2020 Apr;64(4):304-312. doi: 10.1111/1348-0421.12773. Epub 2020 Feb 5. PMID: 31943329.
2020.02	Functional analysis of glycosylation using Drosophila melanogaster. Nishihara S. Glycoconj J. 2020 Feb;37(1):1-14. doi: 10.1007/s10719-019-09892-0. Epub 2019 Nov 26. PMID: 31773367.
2020.01.28	GlyGen: Computational and Informatics Resources for Glycoscience. York WS, Mazumder R, Ranzinger R, Edwards N, Kahsay R, Aoki-Kinoshita KF, Campbell MP, Cummings RD, Feizi T, Martin M, Natale DA, Packer NH, Woods RJ, Agarwal G, Arpinar S, Bhat S, Blake J, Castro LJG, Fochtman B, Gildersleeve J, Goldman R, Holmes X, Jain V, Kulkarni S, Mahadik R, Mehta A, Mousavi R, Nakarakommula S, Navelkar R, Pattabiraman N, Pierce MJ, Ross K, Vasudev P, Vora J, Williamson T, Zhang W. Glycobiology. 2020 Jan 28;30(2):72-73. doi: 10.1093/glycob/cwz080. PMID: 31616925; PMCID: PMC7335483.
2020.01.28	The GlySpace Alliance: toward a collaborative global glycoinformatics community. Aoki-Kinoshita KF, Lisacek F, Mazumder R, York WS, Packer NH. Glycobiology. 2020 Jan 28;30(2):70-71. doi: 10.1093/glycob/cwz078. PMID:31573039; PMCID: PMC6992953.
2019.10.20	Highly sulfated hyaluronic acid maintains human induced pluripotent stem cells under feeder-free and bFGF-free conditions. Miura T, Yuasa N, Ota H, Habu M, Kawano M, Nakayama F, Nishihara S. Biochem Biophys Res Commun. 2019 Oct 20;518(3):506-512. doi: 10.1016/j.bbrc.2019.08.082. Epub 2019 Aug 19. PMID: 31439376
2019.08.20	Updates to the Symbol Nomenclature for Glycans guidelines. Neelamegham S, Aoki-Kinoshita K, Bolton E, Frank M, Lisacek F, Lütteke T, O'Boyle N, Packer NH, Stanley P, Toukach P, Varki A, Woods RJ; SNFG Discussion Group. Glycobiology. 2019 Aug 20;29(9):620-624. doi: 10.1093/glycob/cwz045. PMID: 31184695; PMCID: PMC7335484.
2019.08.15	LM-GlycomeAtlas Ver. 1.0: A Novel Visualization Tool for Lectin Microarray-Based Glycomic Profiles of Mouse Tissue Sections. Nagai-Okatani C, Aoki-Kinoshita KF, Kakuda S, Nagai M, Hagiwara K, Kiyohara K, Fujita N, Suzuki Y, Sato T, Angata K, Kuno A. Molecules. 2019 Aug 15;24(16):2962. doi: 10.3390/molecules24162962. PMID: 31443278; PMCID: PMC6719194.
2019.07.22	Towards a standardized bioinformatics infrastructure for N- and O-glycomics. Rojas-Macias MA, Mariethoz J, Andersson P, Jin C, Venkatakrishnan V, Aoki NP, Shinmachi D, Ashwood C, Madunic K, Zhang T, Miller RL, Horlacher O, Struwe WB, Watanabe Y, Okuda S, Levander F, Kolarich D, Rudd PM, Wuhrer M, Kettner C, Packer NH, Aoki-Kinoshita KF, Lisacek F, Karlsson NG. Nat Commun. 2019 Jul 22;10(1):3275. doi: 10.1038/s41467-019-11131-x. PMID: 31332201; PMCID: PMC6796180.
2019.07.15	Cell Profiling Based on Sugar-Chain-Cell Binding Interaction and Its Application to Typing and Quality Verification of Cells. Shinchi H, Nakamura T, Ota H, Nishihara S, Wakao M, Suda Y. Chembiochem. 2019 Jul 15;20(14):1810-1816. doi: 10.1002/cbic.201900028. Epub 2019 May 21. PMID: 30816597.
2019.07.15	GlycanFormatConverter: a conversion tool for translating the complexities of glycans. Tsuchiya S, Yamada I, Aoki-Kinoshita KF. Bioinformatics. 2019 Jul 15;35(14):2434-2440. doi: 10.1093/bioinformatics/bty990. PMID: 30535258; PMCID: PMC6612873.

招待講演

2019.12.04-06	Shoko Nishihara, Taichi Miura, Hayato Ota, Noriyuki Yuasa, Masato Habu, Federico Pecori, Fumiaki Nakayama, Chika Ogura Function of glycans in pluripotent stem cells 1st International Symposium on Glycans', Zhuhai, China,2019-12-04 to 2019-12-06
2019.11.11-14	Shoko Nishihara, Taichi Miura, Hayato Ota, Noriyuki Yuasa, Masato Habu, Federico Pecori, Fumiaki Nakayama, Chika Ogura Functional analyses of glycans in mammalian stem cells 11th Asian Community of Glycoscience and Glycotechnology Conference, November 11-14, 2019 (Busan, Korea) Invited
2019.09.18-20	西原祥子：多能性幹細胞におけるヘパラン硫酸とO-GlcNAc修飾によるシグナル制御第92回日本生化学会大会、横浜（シンポジウム）
2019.08.25-41	Nishihara S: Functional analysis of mucin-type O-glycans using Drosophila melanogaster the 25th International Symposium on Glycoconjugates (GLYCO XXV), August 25- 31, 2019, Milano, Italy, Invited
2019.08.19-21	西原祥子：糖鎖領域とあらゆる生命科学領域の融合と相互理解、第３８回日本質学会年会、名古屋大学豊田講堂（招待講演）

シンポジウム主催

2022.03.01-03	International Symposium on Microbial Glycoconjugates and the GlySpace Alliance:from micro to macro glycoscience (MiGGA). Organizers：Kiyoko F. Aoki-Kinoshita (GaLSIC, Japan), Kazuhiro Aoki (CCRC, University of Georgia, USA), Yann Guerardel (Lille University, France), Issaku Yamada (The Noguchi Institute, Japan), Masae Hosoda (GaLSIC, Japan) Online event.
2019.09.18-20	シグナルを制御する糖鎖(シンポジウム1S10a) オーガナイザー：灘中里美(神戸薬科大学)、西原祥子(創価大学) 第92回日本生化学会大会シンポジウム、横浜

その他・研究成果

2019.11.18-19

インフルエンザウイルスの宿主間伝播に関わる新規分子機構の解明．
岡松正敏、高瀬明、西原祥子．国立研究開発法人日本医療研究開発機構（AMED）感染症研究革新イニシアティブ（J-PRIDE）研究成果発表会「重症・難治性感染症の理解と予防・治療法の開発に向けて〜若手研究者たちの挑戦〜」（公開）2019年11月18-19日（東京、イイノホール）

所内活動

2019.06.14	学部講演会・生命情報工学専攻勉強会開催
2019.04.12	糖鎖生命システム融合センターキックオフセンターHP　公開
2019.04.08	第１回創価大学糖鎖生命システム融合センター委員会　開催
2019.04.01	創価大学糖鎖生命システム融合センター設立